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The Role Of Nitric Oxide In Physiology And Pathophysiology

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Nitric Oxide

Nitric Oxide Book
Author : Louis J. Ignarro
Publisher : Academic Press
Release : 2000-09-13
ISBN : 9780080525037
File Size : 45,6 Mb
Language : En, Es, Fr and De

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Book Summary :

Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Nitric Oxide in Pulmonary Processes

Nitric Oxide in Pulmonary Processes Book
Author : Maria G. Belvisi,Jane A. Mitchell
Publisher : Springer
Release : 2012-12-06
ISBN : 3034884745
File Size : 35,5 Mb
Language : En, Es, Fr and De

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Book Summary :

Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiological processes. It is released by many cell types in various organs but is particularly important in the maintenance of normal lung function. Nitric oxide in exhaled breath has been identified as a marker for lung disease in some patients. Thus, it is appropriate to consider the lung separately for the role and functioning of nitric oxide. The authors identify key areas in the history, biochemistry, physiology, pathophysiology, immunology and clinical applications of nitric oxide in the lung. The contents of this book will be of particular importance to scientists and clinicians with an interest in lung disease. Moreover, the authors encompass state of the art opinions of and rational for the therapeutic potential of nitric oxide and its inhibitors.

Nitric Oxide and the Kidney

Nitric Oxide and the Kidney Book
Author : Michael S. Goligorsky,Steven S. Gross
Publisher : Springer Science & Business Media
Release : 1997-09-30
ISBN : 9780412080616
File Size : 37,8 Mb
Language : En, Es, Fr and De

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Book Summary :

A number of remarkable recent breakthroughs have made the study of nitric oxide one of the most exciting fields in physiology and pathophysiology. This authoritative edited volume reviews the progress to date and opens perspectives to novel diagnostic and therapeutic strategies. The contributors are leading authorites, in most cases the investigators who have pioneered the ideas explored in the book.

The Role of Nitric Oxide in Physiology and Pathophysiology

The Role of Nitric Oxide in Physiology and Pathophysiology Book
Author : Hilary Koprowski,Hiroshi Maeda
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642791301
File Size : 38,6 Mb
Language : En, Es, Fr and De

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Book Summary :

Nitric Oxide (NO) an endogenous free radical, has been shown recently to mediate several important biological effects. It plays a neuro-transmitter like role in vascular endothelium, a scond-messenger role in N-methyl-D-aspartate (NMDA) responsive neurons in the central nervous system (CNS), a neurotoxic role after its release from these neurons, and a cytotoxic role after its release by macrophages. This volume reviews among other topics the basic chemistry and physical properties of S-nitrosothiols (RS-NO) and their biochemical mechanisms of action, NO synthase isozymes, NO synthase structure, mechanisms of NO synthesis, regulation of NOS expression and posttranslational modification, and mechanisms involving NO of CNS's damage in virus infections.

Gasotransmitters Physiology and Pathophysiology

Gasotransmitters  Physiology and Pathophysiology Book
Author : Anton Hermann,Guzel F. Sitdikova,Thomas M. Weiger
Publisher : Springer Science & Business Media
Release : 2012-07-20
ISBN : 3642303382
File Size : 26,9 Mb
Language : En, Es, Fr and De

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Book Summary :

Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters.

Nitric Oxide in Plants Metabolism and Role in Stress Physiology

Nitric Oxide in Plants  Metabolism and Role in Stress Physiology Book
Author : M. Nasir Khan,Mohammad Mobin,Firoz Mohammad,Francisco J. Corpas
Publisher : Springer
Release : 2014-05-27
ISBN : 3319067109
File Size : 24,5 Mb
Language : En, Es, Fr and De

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Book Summary :

This book covers the key features of nitric oxide (NO) in plants. Comprising nine chapters, Part I highlights its metabolism and identification in plants. Part II, which consists of eight chapters, focuses on the chemical, physical and biochemical properties of the NO molecule and its derivatives; on its functional role and mode of action; and on its signaling and interaction with phytohormones, mineral nutrients, biomolecules, ions and ion channels in plants under abiotic stresses. Combining the expertise of leading researchers in the field, the book provides a concise overview of plant NO biology and offers a valuable reference work.

Nitric Oxide Synthase

Nitric Oxide Synthase Book
Author : Seyed Soheil Saeedi Saravi
Publisher : BoD – Books on Demand
Release : 2017-05-17
ISBN : 953513163X
File Size : 55,8 Mb
Language : En, Es, Fr and De

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Book Summary :

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.

Nitric Oxide and the Cardiovascular System

Nitric Oxide and the Cardiovascular System Book
Author : Joseph Loscalzo,Joseph A. Vita
Publisher : Springer Science & Business Media
Release : 2000-03-29
ISBN : 1592590020
File Size : 30,9 Mb
Language : En, Es, Fr and De

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Book Summary :

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.