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The Secret of Brain Energy

The Secret of Brain Energy Book
Author : Frank C. Haddock
Publisher : Health Research Books
Release : 1988
ISBN : 9780787312855
File Size : 21,6 Mb
Language : Ennglish

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Download The Secret of Brain Energy book written by Frank C. Haddock and published by Health Research Books with total hardcover pages 72 . Available in PDF, EPUB, and Kindle, read book directly with any devices anywhere and anytime.

Brain Energy Metabolism

Brain Energy Metabolism Book
Author : Johannes Hirrlinger,Helle S. Waagepetersen
Publisher : Humana
Release : 2016-09-17
ISBN : 9781493944668
File Size : 38,9 Mb
Language : Ennglish

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Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

Brain Energy Metabolism

Brain Energy Metabolism Book
Author : Bo K. Siesjö
Publisher : John Wiley & Sons
Release : 1978
ISBN : 0987650XXX
File Size : 36,7 Mb
Language : Ennglish

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Download Brain Energy Metabolism book written by Bo K. Siesjö and published by John Wiley & Sons with total hardcover pages 634 . Available in PDF, EPUB, and Kindle, read book directly with any devices anywhere and anytime.

Metabolic Control of Brain Homeostasis

Metabolic Control of Brain Homeostasis Book
Author : Detlev Boison,Jochen C. Meier,Susan A. Masino
Publisher : Frontiers Media SA
Release : 2017-10-03
ISBN : 2889452867
File Size : 27,7 Mb
Language : Ennglish

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Metabolic Control of Brain Homeostasis Book PDF/Epub Download

Brain function is under metabolic control, which in turn determines the equilibrium of homeostatic systems that affect neuronal and glial networks on the molecular, cellular, and systems levels. The collection of articles ranges from molecules and mechanisms involved in regulating homeostasis and neuronal excitability to therapeutic mechanisms tailored to restore homeostatic function. It also features neurological diseases and novel treatment approaches that are based on metabolic and homeostatic interventions. Together, the collection of articles outlines novel strategies to restore brain function in neurology and highlights limitations of conventional pharmacological approaches. We suggest that restoration of molecular and biochemical networks could lead to a new era of therapeutic opportunities.

Human Brain Evolution

Human Brain Evolution Book
Author : Stephen Cunnane,Kathlyn Stewart
Publisher : John Wiley & Sons
Release : 2010-06-01
ISBN : 0470452684
File Size : 45,7 Mb
Language : Ennglish

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Human Brain Evolution Book PDF/Epub Download

The evolution of the human brain and cognitive ability is one of the central themes of physical/biological anthropology. This book discusses the emergence of human cognition at a conceptual level, describing it as a process of long adaptive stasis interrupted by short periods of cognitive advance. These advances were not linear and directed, but were acquired indirectly as part of changing human behaviors, in other words through the process of exaptation (acquisition of a function for which it was not originally selected). Based on studies of the modem human brain, certain prerequisites were needed for the development of the early brain and associated cognitive advances. This book documents the energy and nutrient constraints of the modern brain, highlighting the significant role of long-chain polyunsaturated fatty acids (LC-PUFA) in brain development and maintenance. Crawford provides further emphasis for the role of essential fatty acids, in particular DHA, in brain development, by discussing the evolution of the eye and neural systems. This is an ideal book for Graduate students, post docs, research scientists in Physical/Biological Anthropology, Human Biology, Archaeology, Nutrition, Cognitive Science, Neurosciences. It is also an excellent selection for a grad student discussion seminar.

Homeostatic Control of Brain Function

Homeostatic Control of Brain Function Book
Author : Detlev Boison,Susan Masino
Publisher : Oxford University Press
Release : 2016
ISBN : 0199322295
File Size : 35,6 Mb
Language : Ennglish

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Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

The Power Brain

The Power Brain Book
Author : Ilchi Lee
Publisher : BEST Life Media
Release : 2016-04-15
ISBN : 1935127861
File Size : 42,5 Mb
Language : Ennglish

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Our brains are a thousand times more incredible than anything else we will ever encounter. Every great accomplishment human beings have achieved was the work of the brain. In fact, our brains possess infinite potential that allows us to do and be anything. By using this potential well, we become a “Power Brain” that can not only create our personal fate, but that of the entire planet. To develop our brains’ potential, it’s useful to liken the brain to a computer with an operating system. We have a Brain Operating System (BOS) composed of our beliefs and preconceptions that we can change and upgrade until our brains run optimally. Recognizing the potential in our brain beyond what we’ve been able to use so far, Ilchi Lee began investigating brain development principles and methods. He compiled them into a comprehensive self-development system with five steps called Brain Education. Refined over the years by new scientific research and the experiences of those who use it, Brain Education has become an academic discipline that’s presented in a variety of ways, including school educational programs and corporate training. While The Power Brain is primarily about the brain, this book does not focus on the anatomical or neuro-physiological functions of the brain. Rather, it serves as a Brain Operating System user’s manual that describes how to use our brain to discover our value, recreate the story of our lives, and claim a new destiny. Improving our lives, and consequently, our world, through brain development is a skill that anyone can understand, practice, and apply to everyday life.

Canyon Ranch 30 Days to a Better Brain

Canyon Ranch 30 Days to a Better Brain Book
Author : Richard Carmona
Publisher : Simon and Schuster
Release : 2014-05-06
ISBN : 1451643802
File Size : 48,9 Mb
Language : Ennglish

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Canyon Ranch 30 Days to a Better Brain Book PDF/Epub Download

A guide to staying sharp while aging outlines healthy lifestyle tips, exercises, recipes, and a thirty-day program for maximizing brain function that builds on cognitive science about memory, sleep, stress, and addiction.

Make Your Brain Smarter

Make Your Brain Smarter Book
Author : Sandra Bond Chapman Ph. D.,Sandra Bond Chapman, Ph.D.
Publisher : Simon and Schuster
Release : 2014-01-21
ISBN : 1451665482
File Size : 30,6 Mb
Language : Ennglish

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Make Your Brain Smarter Book PDF/Epub Download

Draws on the latest scientific discoveries to outline tests and exercises for improving cognitive fitness, in a reference that focuses on recent understandings about the frontal lobe to explain how to promote brain health at any age.

Brain Glycogen Metabolism

Brain Glycogen Metabolism Book
Author : Mauro DiNuzzo,Arne Schousboe
Publisher : Springer Nature
Release : 2019-10-31
ISBN : 3030274802
File Size : 33,9 Mb
Language : Ennglish

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Brain Glycogen Metabolism Book PDF/Epub Download

This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.

Survival of the Fattest

Survival of the Fattest Book
Author : Stephen C Cunnane
Publisher : World Scientific
Release : 2005-05-06
ISBN : 9814480827
File Size : 49,8 Mb
Language : Ennglish

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' How did humans evolve larger and more sophisticated brains? In general, evolution depends on a special combination of circumstances: part genetics, part time, and part environment. In the case of human brain evolution, the main environmental influence was adaptation to a 'shore-based' diet, which provided the world's richest source of nutrition, as well as a sedentary lifestyle that promoted fat deposition. Such a diet included shellfish, fish, marsh plants, frogs, bird's eggs, etc. Humans and, and more importantly, hominid babies started to get fat, a crucial distinction that led to the development of larger brains and to the evolution of modern humans. A larger brain is expensive to maintain and this increasing demand for energy results in, succinctly, survival of the fattest. Contents:The Human Brain: Unique Yet Vulnerable:Human Evolution: A Brief OverviewThe Human Brain: Evolution of Larger Size and PlasticityDefining Characteristics: Vulnerability and High Energy RequirementFatness in Human Babies: Insurance for the Developing BrainNutrition: The Key to Normal Human Brain DevelopmentIodine: The Primary Brain Selective NutrientIron, Copper, Zinc and Selenium: The Other Brain Selective MineralsDocosahexaenoic Acid: The Brain Selective Fatty AcidThe Shore-Based Scenario:Genes, Brain Function and Human Brain EvolutionBringing the Environment and Diet into PlayThe Shore-Based Scenario: Why Survival Misses the PointEarlier VersionsThe EvidenceHow Would It Work?Survival of the Fattest Readership: General, and those with an interest in origins of humans especially human intelligence (the big brain). Keywords:Human Brain;Brain Evolution;Dietary Fat;Body Fat;Human Infant;Fat Babies;HominidsKey Features:A new theory of human brain evolutionThe novel concept that shorelines provided a unique food resourceThe novel concept that fat babies were the key to human brain evolutionReviews:“The nutritionist's perspective that brings energy, fatty acid metabolism, and nutrition to the fore makes this account a provocative and fast-paced one. Readers will be challenged and intrigued by this well thought-out volume.”Joyce A Nettleton, DSc, RD ScienceVoice Consulting Denver, Colorado “Anyone interested in how humans evolved will find much of interest in this book … the main thread of the argument seems so plausible that many readers will want to delve further by way of a number of the items listed in the bibliography.”Henry H Bauer Professor Emeritus of Chemistry & Science Studies, Dean Emeritus of Arts & Sciences Virginia Polytechnic Institute & State University “This book is full of interesting facts about our brains and about nutrition and brain and body biochemistry. Cunnane weaves a very complex and multi-faceted hypothesis systematically and relatively clearly … I found the book thought-provoking. It shares data and ideas that are relatively novel and interesting …”European Neurology '

Advances in Brain Stem Research and Application 2013 Edition

Advances in Brain Stem Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481681915
File Size : 51,5 Mb
Language : Ennglish

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Advances in Brain Stem Research and Application 2013 Edition Book PDF/Epub Download

Advances in Brain Stem Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Mesencephalon in a concise format. The editors have built Advances in Brain Stem Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mesencephalon in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Brain Stem Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Omega Fatty Acids in Brain and Neurological Health

Omega Fatty Acids in Brain and Neurological Health Book
Author : Ronald Ross Watson,Victor R. Preedy
Publisher : Academic Press
Release : 2019-06-12
ISBN : 0128152397
File Size : 28,8 Mb
Language : Ennglish

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Omega Fatty Acids in Brain and Neurological Health Book PDF/Epub Download

Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases. Provides a comprehensive introduction to omega-3 and omega-6 fatty acids in neurological health and directions for future research Features novel focus on the adverse effects of omega-6 fatty acids on neurological function and the counterbalancing of dietary and tissue omega-6 Illustrates the importance of omega-3 fatty acids in longevity and cognitive impairment Features new chapters on early effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases Discusses links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements

Brain Rules for Work

Brain Rules for Work Book
Author : John Medina
Publisher : Pear Press
Release : 2021-11-23
ISBN : 1737072874
File Size : 27,7 Mb
Language : Ennglish

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Brain Rules for Work Book PDF/Epub Download

How can I keep people engaged during my presentations? What can I do to my office so that I look forward to coming to it on Monday? How can I improve the productivity of our team, our department, our company? Scientists know. Brain Rules for Work by developmental molecular biologist and author Dr. John Medina, explores the various aspects of work through the lens of peer-reviewed science. Having written New York Times bestselling works Brain Rules, Brain Rules for Baby and Brain Rules for Aging Well, Dr. Medina turns his expertise towards the professional world, guiding us through what brain science and evolutionary biology have to say about topics from office space and work/life balance to power dynamics and work interactions in the time of COVID-19. Medina's charming descriptions and hilarious anecdotes break the science down to practical applications that you can put into use next Monday to improve your work life and the work lives of those around you. You'll learn: Why taking breaks in nature during the workday improves productivity How planning a meeting beforehand makes it more effective Why an open office plan isn't a good office plan How a more diverse team is a more potent team What exactly about talking to co-workers online is so exhausting Why allowing for failure is vital to a company's success What power can do to an executive who has just been promoted Procrastination is not due to laziness, rather an avoidance of negative feelings Which personality tests will help you find the right fit for the job-hint: it's not the Myers-Briggs The surprising source of a leader's charisma And what our work lives will look like in a post-pandemic world Whether you are an employee at a company looking to become successful or an executive who wants to ensure the success of your employees, Brain Rules For Work is both a useful tool and a compelling guide for you and your co-workers.

Electric Brain

Electric Brain Book
Author : R. Douglas Fields
Publisher : BenBella Books
Release : 2020-02-04
ISBN : 1948836297
File Size : 38,6 Mb
Language : Ennglish

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Electric Brain Book PDF/Epub Download

What is as unique as your fingerprints and more revealing than your diary? Hint: Your body is emitting them right now and has been every single day of your life. Brainwaves. Analyzing brainwaves, the imperceptible waves of electricity surging across your scalp, has been possible for nearly a century. But only now are neuroscientists becoming aware of the wealth of information brainwaves hold about a person's life, thoughts, and future health. From the moment a reclusive German doctor discovered waves of electricity radiating from the heads of his patients in the 1920s, brainwaves have sparked astonishment and intrigue, yet the significance of the discovery and its momentous implications have been poorly understood. Now, it is clear that these silent broadcasts can actually reveal a stunning wealth of information about any one of us. In Electric Brain, world-renowned neuroscientist and author R. Douglas Fields takes us on an enthralling journey into the world of brainwaves, detailing how new brain science could fundamentally change society, separating fact from hyperbole along the way. In this eye-opening and in-depth look at the most recent findings in brain science, Fields explores groundbreaking research that shows brainwaves can: • Reveal the type of brain you have—its strengths and weaknesses and your aptitude for learning different types of information • Allow scientists to watch your brain learn, glean your intelligence, and even tell how adventurous you are • Expose hidden dysfunctions—including signifiers of mental illness and neurological disorders • Render your thoughts and transmit them to machines and back from machines into your brain • Meld minds by telepathically transmitting information from one brain to another • Enable individuals to rewire their own brains and improve cognitive performance Written by one of the neuroscientists on the cutting edge of brainwave research, Electric Brain tells a fascinating and obscure story of discovery, explains the latest science, and looks to the future—and the exciting possibilities in store for medicine, technology, and our understanding of ourselves.

Brain and Memory

Brain and Memory Book
Author : Anonim
Publisher : Phil Dove
Release : 2023-06-04
ISBN : 0987650XXX
File Size : 24,8 Mb
Language : Ennglish

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Brain and Memory Book PDF/Epub Download

As our body needs exercise and a healthy diet to stay in shape so also our brain needs exercise and proper nutrition. And if in terms of our body we can afford a few extra pounds, which we can take off if we decide to do this, not as happens with our mind. Unfortunately this does not receive the proper attention.

Solving the Brain Puzzle

Solving the Brain Puzzle Book
Author : Bill Code,Karen D. Johnson M.D.,Teri Jaklin ND
Publisher : FriesenPress
Release : 2019-01-21
ISBN : 1525527258
File Size : 45,6 Mb
Language : Ennglish

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Solving the Brain Puzzle Book PDF/Epub Download

Receiving a diagnosis of multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, or some other brain-related illness is devastating. It feels like life, as you know it, is over, and you are powerless to do anything about it. Your future may seem like nothing but a long black tunnel of decreasing cognitive function, declining mobility, depression, and premature death. Even your physician may share this gloomy view. The good news is, you have more control over your brain health than you think! With the exception of cancer, many brain illnesses can be reversed through a combination of diet, exercise, supplements, proper sleep, avoiding and removing toxins from the body, and taking an epigenetic (turning good genes on and not-so-good genes off) approach to your healing. Several “jump start” techniques, including oxygen therapy, microbiota therapy (Gut Flora Transplant or GFT), photobiomodulation therapy (PMT), venous angioplasty, and even cannabis can enhance your recovery in as little as a few weeks. Never before have we had so many safe approaches with little or no side effects. Best of all, these treatments are now available on almost every continent, including Europe, Asia, Australia, and North America. It is time we let go of our paternalistic concept that “doctor knows best.” This book describes all the above treatments and more, providing a roadmap to enhance your brain recovery. You may not feel like it right now, but you can win the brain game, and this book can show you how!

Unlocking the Brain Volume 2 Consciousness

Unlocking the Brain  Volume 2  Consciousness Book
Author : Georg Northoff
Publisher : Oxford University Press
Release : 2013-11-11
ISBN : 0199383987
File Size : 20,7 Mb
Language : Ennglish

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Unlocking the Brain Volume 2 Consciousness Book PDF/Epub Download

Neuroscience has made considerable progress in figuring out how the brain works. We know much about the molecular-genetic and biochemical underpinnings of sensory and motor functions. Recent neuroimaging work has opened the door to investigating the neural underpinnings of higher-order cognitive functions, such as memory, attention, and even free will. In these types of investigations, researchers apply specific stimuli to induce neural activity in the brain and look for the function in question. However, there may be more to the brain and its neuronal states than the changes in activity we induce by applying particular external stimuli. In Volume 2 of Unlocking the Brain, Georg Northoff addresses consciousness by hypothesizing about the relationship between particular neuronal mechanisms and the various phenomenal features of consciousness. Northoff puts consciousness in the context of the resting state of the brain thereby delivering a new point of view to the debate that permits very interesting insights into the nature of consciousness. Moreover, he describes and discusses detailed findings from different branches of neuroscience including single cell data, animal data, human imaging data, and psychiatric findings. This yields a unique and novel picture of the brain, and will have a major and lasting impact on neuroscientists working in neuroscience, psychiatry, and related fields.

Welcome to Your Brain

Welcome to Your Brain Book
Author : Sandra Aamodt,Sam Wang
Publisher : Bloomsbury Publishing USA
Release : 2010-06-01
ISBN : 1596917067
File Size : 36,7 Mb
Language : Ennglish

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Welcome to Your Brain Book PDF/Epub Download

Does drinking really kill brain cells? Does listening to Mozart make your baby smarter? For all the mileage we've gotten from our own brains, most of us have essentially no idea how they work. We're easily susceptible to myths (like the "fact" that we use only 10% of our brains) and misconceptions (like the ones perpetrated by most Hollywood movies), probably because we've never known where to turn for the truth. But neurologists Sandra Aamodt and Sam Wang are glad to help. In this funny, accessible book, we get a guided tour of our own minds, what they're made of, how they work, and how they can go wrong. Along the way, we get a host of diagrams, quizzes, and "cocktail party tips" that shed light on the questions we nag each other about. (Can a head injury make you forget your own name? Are dolphins smarter than chimpanzees?) Fun and surprisingly engrossing, Welcome to Your Brain shows you how your brain works, and how you can make it work better.

PH and Brain Function

PH and Brain Function Book
Author : Kai Kaila,Bruce R. Ransom
Publisher : John Wiley & Sons
Release : 1998-09-15
ISBN : 9780471118381
File Size : 55,6 Mb
Language : Ennglish

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PH and Brain Function Book PDF/Epub Download

"PH and Brain Function offers thorough coverage of this increasingly important area of research, beginning with the fundamental concepts, which include methodological and theoretical issues such as the measurement of pH and the concept of pH in neurobiology. It explores aspects of regulation and modulation of intracellular pH in brain cells, surveys the changes in pH that occur with neural activity and how these changes affect neural activity, and discusses the role of pH in the pathophysiology of neurological diseases." "pH and Brain Function is an important resource for researchers in all areas of neuroscience as well as cell biology and physiology." --Book Jacket.

Cellular Molecular Physiological and Behavioral Aspects of Traumatic Brain Injury

Cellular  Molecular  Physiological  and Behavioral Aspects of Traumatic Brain Injury Book
Author : Rajkumar Rajendram,Victor R. Preedy,Colin R. Martin
Publisher : Academic Press
Release : 2022-05-10
ISBN : 0128230606
File Size : 25,6 Mb
Language : Ennglish

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Cellular Molecular Physiological and Behavioral Aspects of Traumatic Brain Injury Book PDF/Epub Download

Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury. Summarizes the neuroscience of traumatic brain injury, including cellular and molecular biology Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on signaling and hormonal events Includes plasticity and gene expression Examines health and stress behaviors after traumatic brain injury